Jurnal Health Sains

Thoracal Spinal Fusion In Tuberculous Spondylitis With Pulmonary Oedema And Thrombocytosis: A case report

Pieter Julius Daely — 2025-02-01

TB is caused by Mycobacterium tuberculosis (M. tb). Tuberculosis (TB) prevalence is increasing in developed nations and continuing to cause significant mortality in low and middle income countries. When M. tb disseminates to the vertebral column, it is called Pott’s disease or spinal TB. The frequency, symptoms, and severity of the disease range by the location of the spine and the region of the affected vertebrae. The delay in establishing diagnosis and management results in complications such as spinal cord compression and spinal deformity. Tuberculous spondylitis is the most dangerous form of musculoskeletal tuberculosis because it can cause bone destruction, deformity and paraplegia. The spread of tuberculosis infection will cause inflammation in paradiscs, and causes progressive bone destruction and then will make vertebral collapse and deformity arising shaped kyphosis (posterior angulation) called gibbus. The role of surgical debridement and fusion with TB is controversial, and good results may be obtained with either medical treatment or surgery. Surgery may be more appropriate when definite cord compression is documented or for complications such as abscess or sinus formation or spinal instability.

Neutrophil Lymphocyte Ratio as a Predictor of Chronic Low Back Pain Severity

Putu Setiani — 2025-01-31

Low back pain is a frequently seen problem in the society and causes loss of productivity. In recent studies, inflammatory mediators and inflammation itself has an efficient role in pain mechanism. We aimed to investigate the association between the neutrophil to lymphocyte ratio level as an inflammatory biomarker with pain severity patients with chronic low back pain. A retrospective analysis was conducted on medical records of low back pain patients between Januari until December 2024 in Neurology Department of Bhakti Rahayu Denpasar Hospital. Seventy-three medical record patients between 27-81 years old were included in the study. The neutrophil-to-lymphocyte ratio (NLR) is calculated by dividing the absolute neutrophil count by the absolute lymphocyte count based on blood samples. The patients were divided into two groups based on pain severity. The average age of the participants was 56,63 years (±15,56) (p= 0,077), with 40 males (54,85) and 33 females (45,2%) with average neutrophil count 5,99 x 10⁹/L (±1,45) (p= 0,200) and lymphocyte count 1,75x 10⁹/L (±0,39) (p= 0,093). NLR cut-off was 3,55 (±0,72) (p= 0,200). Higher NLR correlated with age (r = 0.243, p = 0.038) and pain score (r = 0.394 p < 0.001). High NLR increased the risk of 33, 43 LBP patients experiencing moderate pain (p= <0.001). NLR may be used as a simple and reliable premise independent predictor of pain severity in patients with chronic low back pain

THE USE OF TRADITIONAL DHSP BALI YOGA AND MEDITATION PRACTICES ON REDUCING BLOOD GLUCOSE LEVELS

Agung Setiabudi — 2025-01-31

The practice of yoga and meditation at Dharma Hidup Singin Prana Bali has a deep meaning in maintaining physical and mental balance, as well as supporting mental health in the midst of the dynamics of modern life. Yoga has been shown to be effective in helping to manage blood sugar levels through meditation and yoga practices. This study uses quantitative research methods, specifically using a quasi-experimental design with pre-test and post-test, to assess the results before and after the intervention for the purpose of evaluating blood sugar levels from the results of yoga and meditation exercises. Descriptive analysis of 32 samples showed that the mean glucose values after the intervention showed a decrease. Statistical analysis of Kolmogorov-Smirnov pre-test with P = 0.183 data showed normal and homogeneous distribution. The test of the difference in the results of the pre-test and post-test research using the Paired sample T-test analysis with 95% confidence showed significance = 0.000 Because the significance result of 0.000 which means < 0.001 where 0.001<0.05 so that there is a statistically significant difference. Traditional Dhsp Bali yoga and meditation exercises involving breathing exercises, postures and Yoga have been shown to be effective against the balance and decrease of glucose levels in the blood.

The Relationship Between Hemoglobin Levels and Early Mobilization on Surgical Wound Healing in Post Sectio Caesarea Patients at Metta Medika Padangsidimpuan Hospital

Dianra Milani — 2025-02-05

This study aims to analyze the relationship between hemoglobin (Hb) levels and early mobilization on surgical wound healing in post-sectio caesarean section patients. The research design uses a quantitative approach with a cross-sectional analytical observational method. The study was conducted at Metta Medika Padangsidimpuan Hospital on 33 patients who were selected using the purposive sampling technique. The data was analyzed by the Chi-Square test to determine the relationship between variables. The results showed that the Hb level ≥ 11 g/dl was related to better healing of surgical wounds compared to Hb < 11 g/dl (p = 0.013). In addition, rapid and normal early mobilization significantly improved wound healing compared to slow mobilization (p = 0.025). This study concluded that Hb levels and early mobilization had a significant relationship with wound healing in post-sectio caesarean section. These findings can be used as a reference in postoperative management to improve the quality of patient recovery.

Implementation of Color in the Interior Design of the Pharmacy Laboratory through a Total Ergonomics Approach provides Comfort and Increases Focus in Work

Made Ida Mulyati — 2025-02-01

Interior design is not only limited to arranging the room to make it look attractive. There are fundamental reasons why we need interior design, which must be able to create a room that is harmonious, aesthetic, meets the demands of its activities and the psychological demands of its community so that the room is functional. The furniture and equipment facilities of the pharmaceutical laboratory have been standardized. For color standardization does not yet exist, it is necessary to analyze the color in the interior design of the pharmaceutical laboratory through a total ergonomics approach to be able to provide comfort and focus for staff. The method used is descriptive analysis method. Color psychology is a theory of color studies related to human psychology. To balance the room, it must also be considered the appropriate color implemented in interior design to achieve balance and harmony in the room. Designing the interior of a pharmaceutical laboratory is not just about implementing the colors we like, but must have sufficient meaning so that it can have an impact on behavior, mood, cognition, focus, and general association. For this reason, it is considered important to study the total Ergonomics approach in order to get the optimal improvement solution. The results of the analysis obtained colors that are suitable to be applied to the interior of the pharmaceutical laboratory include neutral colors of white, light gray, and may slightly apply black as an accent. Besides there are several companion colors to be combined with neutral colors including white heron, crystalline, windmill wings, golden straw, thunder. By implementing these colors, it can provide comfort and focus for laboratory staff to improve performance and productivity.

Comparison of the Effectiveness Between Surgical Therapy and Conservative Therapy in the Management of Tuberculosis Spondylitis: A Comprehensive Systematic Review and Meta-Analysis

Gede Ricky Ananta Herryadi — 2025-02-04

Spinal tuberculosis (TB) is the most common form of skeletal TB, with the thoracolumbar junction being the most frequently affected region, while cervical spine TB remains relatively rare, accounting for only 3% to 5% of cases. Historically, non-operative treatment was the only option in the pre-antibiotic era. However, with the introduction of effective combination chemotherapy in the early 1950s, the mortality rate for spinal TB significantly decreased to 1%–3%. Despite advancements in medical therapy, surgical intervention remains crucial in cases involving neurological complications and kyphosis prevention, with instrumentation playing an integral role in managing spinal pathologies.

This study aims to evaluate the effectiveness of surgical therapy versus conservative therapy in the management of tuberculosis spondylitis through a systematic review and meta-analysis following PRISMA guidelines and the PICO format. The research includes randomized controlled trials (RCTs), observational, quasi-experimental, and case-control studies, while studies not directly assessing treatment effectiveness were excluded. A comprehensive literature search using PubMed, Sage Journal, The Lancet, and ScienceDirect initially retrieved 1,499 publications. Through a rigorous three-stage screening process, only 10 articles published between 2014 and 2024 were selected for final analysis.

The findings indicate that both conservative anti-TB drug therapy and surgical treatment are safe and effective, particularly for early-diagnosed patients with fewer affected vertebrae. Conservative therapy provides good clinical and radiological outcomes, while surgical intervention offers advantages such as thorough debridement, spinal cord decompression, and improved spinal stabilization. The implications of this study suggest that treatment selection should be tailored based on disease severity and patient-specific conditions. Further research should focus on long-term comparative studies, minimally invasive surgical techniques, and biomechanical modeling to optimize treatment strategies for spinal TB..

The Effect of Platelet Aditive Solution In Maintaining the Quality and Function of Concentrated Platelets In The Pooling Method of Buffy Coat Leukofiltered

Idah Wido Sari Nawangsih — 2025-02-04

The availability of platelets in the Indonesian Red Cross (PMI) Blood Transfusion Unit (UDD) has been significantly high, with 767,680 bags collected in 2019, increasing to 957,397 bags in 2021. The dengue fever outbreak alongside the COVID-19 pandemic led to a nearly twofold increase in the demand for concentrated platelets (TP) in hospitals from 2021. However, platelet additive solution (PAS), which can extend platelet shelf life, is not yet utilized in Indonesia. This study aims to investigate whether TP obtained using the buffy coat leukofiltered pooling method and stored with PAS can improve platelet quality during storage. A series of laboratory tests were conducted to evaluate platelet count, pH levels, and aggregation function using ADP inspection, monitored over a storage period from day zero to day seven. The results indicate that the addition of PAS effectively maintains platelet quality, pH stability, and platelet function throughout the storage duration. This is attributed to the nutrient-rich composition of PAS, which contains glucose, sodium acetate, sodium chloride, phosphate, magnesium, and potassium, ensuring the preservation of platelet integrity. The findings highlight the potential benefits of PAS implementation in Indonesia to enhance platelet storage efficiency and availability, particularly during periods of high demand. Future research should explore the optimal PAS formulation for different storage conditions, cost-effectiveness, and clinical efficacy in transfusion settings to support broader adoption of this technology in blood banking.