Jurnal Health Sains

THE EFFECT OF RESISTANCE TRAINING AND ANTIOXIDANT SUPPLEMENTATION WITH ASTAXANTHIN ON PLASMA MALONDIALDEHYDE (MDA) LEVELS IN ADULTS

2025-03-19T02:03:35+00:00

Resistance training has grown in importance for managing oxidative stress, particularly in adults, as it enhances muscle development and overall health. However, it also leads to the formation of reactive oxygen species (ROS), which can result in cellular oxidative damage and potentially hasten the aging process. This review assesses the role of astaxanthin, a powerful antioxidant, in counteracting oxidative stress during resistance training, with a focus on its effects on aging. This study employs a narrative review methodology, evaluating peer-reviewed publications from 2019 to 2024. Keywords used include "Aging," "Antioxidant," "Astaxanthin," "Oxidative Stress," and "Adults." Twenty-five articles were selected for in-depth analysis. The findings suggest that astaxanthin supplementation notably decreases oxidative stress markers, particularly plasma malondialdehyde (MDA) levels, in individuals undergoing resistance training. On a molecular level, astaxanthin activates the Nrf2 pathway, which is responsible for regulating antioxidant enzyme production and supports mitochondrial biogenesis through the PGC-1α pathway. This dual mechanism not only reduces oxidative damage but also enhances energy metabolism, helping maintain cellular function and delaying age-related decline. In conclusion, incorporating astaxanthin supplements into resistance training routines offers promising potential for reducing oxidative stress and promoting healthy aging in adults.

UNILATERAL TONSIL ENLARGEMENT MIMICKING MALIGNANCY: A CASE REPORT

2025-03-30T04:36:52+00:00

Unilateral Tonsil Enlargement (UTE) can present clinically as a significant challenge in differentiation between benign and malignant processes. The suspicion of malignancy increases in older patients who are symptomatic. The purpose of this study was to show that unilateral tonsillar hypertrophy does not always indicate malignancy. A 51-year-old woman presented with a recurring sore throat, but it has been persistent for the past 1 month. A globus sensation accompanied the complaint. On Ear, Nose, and Throat (ENT) examination, the right tonsil grade was T2 and the left tonsil was T4, hyperemic, with dilated crypts. The patient was referred before with a working diagnosis of unilateral tonsil hypertrophy suspect malignancies, with a planned tracheostomy. The literature search was conducted on PubMed, Cochrane, Scopus using keywords “unilateral tonsil enlargement” and “tonsil hypertrophy” and “tonsil asymmetry” in the last 10 years. Based on the investigation, it was found that tonsillectomy for asymptomatic Unilateral Tonsil Enlargement does not need to be performed immediately. Given that the occurrence of malignancy in asymmetrical tonsils is minimal in the absence of additional risk factors, a period of watchful waiting may be deemed appropriate before considering any surgical intervention. It is recommended to observe for four weeks.

PHACOMORPHIC GLAUCOMA WITH SENILE IMMATURE CATARACT: A CASE REPORT

2025-03-08T03:19:32+00:00

Phacomorphic glaucoma is a secondary angle-closure glaucoma caused by lens thickening due to cataract formation process, potentially leading to increased intraocular pressure and a risk of permanent optic nerve damage, resulting in visual impairment. This report discusses a case involving a 57-year-old female presenting with blurred vision and pain in one eye, diagnosed with phacomorphic glaucoma with senile immature cataract based on history taking, and ophthalmological examination. The findings revealed decreased visual acuity, lens opacity in the left eye with a positive shadow test, increased iop, and shallow anterior chamber. the patient initially received medical therapy to lower intraocular pressure, followed by definitive treatment, which consisted of a combination of phacoemulsification with intraocular lens implantation and trabeculectomy. postoperative results showed symptom and visual acuity improvement, although the prognosis for visual function depends on the degree of optic nerve damage prior to treatment. primary management of phacomorphic glaucoma involves cataract extraction, which causes pupil block, that is often combined with trabeculectomy to effectively control intraocular pressure.